CYP 11A1

《英文MSH詞典》CYP 11A1
[入口詞] CYP 11A1
[主題詞] Cholesterol Side-Chain Cleavage Enzyme
[英文釋義] A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 CHOLESTEROL to C21 PREGNENOLONE in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme,encoded by CYP11A1 gene,catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.